Liquid chromatography–mass spectrometry (LCMS, or alternatively HPLC-MS) is a chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry. LC-MS is a powerful technique used for many applications which has very high sensitivity and selectivity. Generally its application is oriented towards the general detection and potential identification of chemicals in the presence of other chemicals (in a complex mixture). Preparative LCMS system can be used for fast and mass directed purification of natural-products extracts and new molecular entities important to food, pharmaceutical, agrochemical and other industries. The limitations of LCMS in urine analysis drug screening is that it often fails to distinguish between specific metabolites, in particular with hydrocodone and its metabolites. LCMS urine analysis testing is used to detect specific categories of drugs. However, gas chromatography (GC-MS) should be used when detection of a specific drug and its metabolites is required.
The Agilent 1100 Series HPLC System is designed to continuously enhance the productivity of laboratories by providing consistent results and optimum instrument performance. This Agilent 1100 modular series guarantees efficient mixing and pulse-free solvent delivery which provides users with fast and accurate results. The 1100 series system is integrated with an electronically activated inlet valve which is synchronized to piston strokes and is able to eliminate vapour formation in volatile solvents. It also features a high-speed proportioning valve and a pre-configured vacuum degasser. The series is designed to be operated with a hand-held controller or computer running Clarity software which enable smooth and efficient operation. With this high functioning and innovative system, the Agilent HPLC 1100 is remarkably easy-to-use and maintenance-free.